Make the Pinwheels: Preheat the oven to 400 degrees F. Line large rimmed baking pan with parchment paper.

Unroll pizza dough into a rectangle (about 13x9 inches). Spread pizza sauce evenly over dough, leaving a 1/2-inch border on all sides. Sprinkle with mozzarella, 1/4 cup Parmesan, Italian seasoning and crushed red pepper flakes, if using. Arrange pepperoni in a single layer on top.

Starting at the bottom edge, roll dough sheet up like a jelly roll. Using a serrated knife, cut roll crosswise into 3 pieces, then cut each section crosswise into 4 pieces, for a total of 12 pieces.

Arrange pieces flat on prepared baking pan. Transfer to oven and bake 12 to 15 minutes or until golden and bubbly.

Meanwhile, in small bowl, stir together melted butter and garlic until well combined.

When pinwheels come out of oven, immediately brush with garlic butter and sprinkle with basil and remaining 2 tablespoons Parmesan. Serve warm, or at room temperature, with Pesto Ranch for dipping.